罗凯，广州医科大学附属肿瘤医院检验科，主任技师，硕士生导师
基本情况简介：
在广州医科大学附属肿瘤医院检验科工作十五年，担任检验科副主任、广东省基层医药学会检验专业委员会副主任委员、广东省精准医学应用学会临床生物信息分会常务委员、广东省精准医学应用学会罕见肿瘤分会常务委员、广东省卫生经济学会检验经济分会常务委员、
广东省医学会精准医学与分子诊断学分委会委员、广州市医师协会检验医师分会副主任委员、广州市医学会微生物学与免疫学分会副主任委员、广州市医院协会检验专业委员会副主任委员、广州市医学会检验医学分会常务委员、广州市医学会检验医学分会新技术学组组长、广州市医学会精准分子诊断学分会常务委员。
主持国家和省部级课题1项，发表论文二十余篇，获得专利授权4项。
联系方式:电话020-66673666；邮箱luokainan@126.com；
研究领域
肿瘤生物标志物筛选、检测与靶向治疗耐药机制研究
科研项目
1、广东省基础与应用基础研究项目，Circ-WHSC1调控非小细胞肺癌奥希替尼耐药的机制及其作为耐药标志物的临床价值，2023年-2026年，10万
代表性论著（*第一作者，#通讯作者）
(1) Xiaoting Jia *, Jingjie Tian * , Pingping Chen * , Jing Dong , Lei Li , Danyang Chen , JianleiZhang , DongjiangLiao# , ZhiminHe# , KaiLuo#.Methylation-modulated PFTK1 regulates gefitinib resistance via Wnt/β-catenin signaling in EGFR mutant non-small-cell lung cancer cells, Commun Biol, 2024, 7(1):1649.
(2)Siwen Fan *, Xinwu Lv * , Chuantao Zhang * , Bingbing Zeng , Yanqing Liang , Danyang Chen , Zumin Xu , Pan Li , Shanshan Wu , Hao Liu , Kai Luo# , Zongcai Liu #, Yanmei Yi#. METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells, Mol Cancer Res, 2024,22(11):1051-1063.
(3) Ting Zhu* , Junjun Wang* , Juan Li* , Qichao Zhang , YanyanShang, Junhao Zhou , Ling Min , Bo Lv# , Kai Luo# . A serum LncRNA signature for predicting prognosis of triple-negative breast cancer, Clin Chim Acta, 2023,549:117535.
(4) Hao Liu* , Xiaoting Jia* , Kai Luo* , Xiangzhou Chen , Zhijie Zhang , Danyang Chen, Yixue Gu, Zhimin He#, Guopei Zheng#. TCRP1 activated by mutant p53 promotes NSCLC proliferation via inhibiting FOXO3a, Oncogenesis,2022,11(1):19.
(5) Jun Wang* , Xi Liu* , Yuanfeng Huang*, Pan Li , Minqiang Yang , Shanshan Zeng , DanyangChen , QianWang, HaoLiu# , Kai Luo# , Jin Deng#. Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells, Cell Death Discov, 2022, 8(1): 170.
(6) Yanmei Yi*, Pan Li*, Yuanfeng Huang*, Danyang Chen, Siwen Fan, Jun Wang,Minqiang Yang, Shanshan Zeng, Jin Deng, Xinwu Lv, Kai Luo#, Zhiwei He#, Hao Liu#. P21-activated kinase 2-mediated β-catenin 1 signaling promotes cancer stemness and osimertinib resistance inEGFR-mutant non-small-cell lung cancer, Oncogene, 2022, 41(37):4318-4329.https://doi.org/10.1038/s41388-022-02438-z.
(7) Ting Liu*, Wei Guo*, Kai Luo*, Lei Li, Jing Dong , Meijun Liu, Xingyuan Shi, Zhiyuan Wang , Jianlei Zhang , Jiang Yin, Ni Qiu , Minying Lu , Danyang Chen, Xiaoting Jia, Hao Liu , Yixue Gu , Yan Xiong , Guopei Zheng , Gang Xu# , Zhimin He# , Zhijie Zhang#. Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer, Int J Biol Sci, 2022, 18(11): 4497-4512.
(8) Jianlei Zhang*, Liyun Luo*, Jing Dong, Meijun Liu, Dongfeng Zhai, Danqing Huang, Li Ling, Xiaoting Jia, Kai Luo#, Guopei Zheng#.A prognostic 11-DNA methylation signature for lung squamous cell carcinoma [J]. Journal of Thoracic Disease,2020,12(5):2569-2582.
