李明川，广州医科大学附属肿瘤医院肿瘤研究所，教授，硕士生导师
基本情况简介：
博士，广州医科大学“南山学者”骨干人才。主要研究方向为磷脂代谢在癌症、抗癌药物心肌毒性中的作用和分子机制。近年在Circulation、Cardiovascular Research、Science Translational Medicine等期刊累计发表研究论文20余篇。主持国家自然科学基金青年基金项目，广东省基础与应用基础研究基金项目等。担任中国生物化学与分子生物学会脂质与脂蛋白专业分会青年委员；《解放军医学》杂志青年编委；Cardiovascular Research、Oxidative Medicine and Cellular Longevity等杂志审稿人。
联系方式:mingchuanli@gzhmu.edu.cn
研究领域
磷脂代谢与细胞信号转导
科研项目
1. 广州医科大学“南山学者”骨干人才配套经费，2023.03-2028.03，300万，主持
2. 国家自然科学基金青年基金项目，2021.01-2023.12，24万，主持
3. 广东省基础与应用基础研究基金联合基金青年基金项目，2020.01-2022.12，9万，主持
代表性论著（*第一作者，#通讯作者）
1. Li M, Sala V, De Santis MC, Cimino J, Cappello P, Pianca N, Di Bona A, et al. Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth. Circulation. 2018, 138(7):696-711. (IF: 37.8)
2. Huang J, Wu R, Chen L, Yang Z, Yan D#, Li M#. Understanding Anthracycline Cardiotoxicity From Mitochondrial Aspect. Frontiers in Pharmacology. 2022, 13: 811406. #Corresponding Authors (IF: 5.810)
3. Zhu B, Zhong W, Cao X, Pan G, Xu M, Zheng J, Chen H, Feng X, Luo C, Lu C, Xiao J, Lin W, Lai C, Li M, Du X, Yi Q, Yan D. Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice. Science Translational Medicine. 2022, 14(629):eabh2548. (IF: 17.956)
4. Zhong W, Cao X, Pan G, Niu Q, Feng X, Xu M, Li M, Huang Y, Yi Q, Yan D. ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1. Blood. 2022, 139(7):1052-1065. (IF: 22.113)
5. Li M, Russo M, Pirozzi F, Tocchetti CG, Ghigo A. Autophagy and cancer therapy cardiotoxicity: From molecular mechanisms to therapeutic opportunities. BBA-Molecular Cell Research. 2020, 1867(3):118493. (IF: 4.739)
6. Russo M, Guida F, Paparo L, Trinchese G, Aitoro R, Avagliano C, Fiordelisi A, Napolitano F, Mercurio V, Sala V, Li M, Sorriento D, Ciccarelli M, Ghigo A, Hirsch E, Bianco R, Iaccarino G, Abete P, Bonaduce D, Calignano A, Berni Canani R, Tocchetti CG. The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity. European Journal of Heart Failure. 2019, 21(4):519-528. (IF：13.965)
7. Ghigo A, Laffargue M, Li M, Hirsch E. PI3K and Calcium Signaling in Cardiovascular Disease. Circulation Research. 2017, 121(3):282-292. (IF: 15.862)
8. Li M*, Murabito A*, Ghigo A, Hirsch E. PI3Ks in Diabetic Cardiomyopathy. Journal of Cardiovascular Pharmacology. 2017, 70(6):422-429. *equal contributors (IF: 2.371)
9. Ghigo A*, Li M*, Hirsch E. New signal transduction paradigms in anthracycline-induced cardiotoxicity. BBA-Molecular Cell Research. 2016, 1863(7):1916-25. *equal contributors (IF: 4.739)
10. Li M, Hirsch E. Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis. Cardiovascular Research. 2015, 105:129–130. (IF: 10.787)
11. Ghigo A, Li M. Phosphoinositide 3-kinase: Friend and foe in cardiovascular disease. Frontiers in Pharmacology. 2015, 6:169. (IF：3.845)
12. Li M-C*, Liu Q-Q*, Zhang Y-L, Wang L-L, Lu X-Y. Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 Immobilized PHA nanoparticles as immune activation agent. BMC Biotechnology. 2012, 12:43. *equal contributors (IF: 2.303)
