李楠，广州医科大学附属肿瘤医院内三科，副主任医师，硕士生导师
基本情况简介：
毕业于中南大学，获博士学位。在广州医科大学附属肿瘤医院内三科工作13年，担任广东省抗癌协会靶向治疗专委会常务委员，广东省抗癌协会大肠癌专委会委员，广东省中西结合学会生物治疗专委会青年委员，广州市医学会肿瘤学分会委员兼秘书，广州市抗癌协会青年委员会委员。主持国家和省部级课题5项（在研2型，研究经费50万元），近5年第一作者或通讯作者发表SCI收录论文4篇，获得专利授权1项。
联系方式:邮箱linan_gz2013@163.com；
研究领域
1、肿瘤微环境与肿瘤免疫
科研项目
1. 广东省自然科学基金, 青年提升项目, 2023A151503005, LPCAT2抑制结直肠癌发生发展的肿瘤本身和肿瘤微环境机制研究, 2023-01 至 2025-12, 30万元, 在研, 主持
2. 广东省自然科学基金, 面上项目, 2021A1515010988, S100A8/FOXP1信号介导肿瘤细胞与巨噬细胞交互促进结直肠癌进展, 2021-01 至 2023-12, 10万元, 结题, 主持
3. 市校联合项目，LPCAT2在肿瘤细胞和巨噬细胞交互调控结直肠癌发生发展中的作用机制及生物学意义，2023-04至2025-04，20万元，在研，主持
代表性论著（*第一作者，#通讯作者）
1. Cao Nan, Zhang Fangmei, Yin Jiang, Zhang Jianlei, Bian Xiqing, Zheng Guopei, Li Nan#, Lin Ying, Luo Liyun. LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11axis, ONCOGENE, 2024, 43(22): 1714-1725
2. Nan Li*, Guohua Yang, Liyun Luo, Li Ling, Xiaorong Wang, lejuan Shi, Junsong Lan, Xiaoting Jia, Qiong Zhang, Ze Long, Jinbao Liu, Weimin Hu, Zhimin He, Haiying Liu, Wangqing Liu, GuopeiZheng. LncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP, Clinical Cancer Research, 2020,26(7): 1736-1748.
3. Nan Li*, Nanrong Yu, Jia Wang, Haofeng Xi, Weiqun Lu, Houwei Xu, Min Deng, Guopei Zheng, Haiying Liu. MiR-222/VGLL4/YAP-TEAD1 regulatory loop promotes proliferation and invasion of gastric cancer cells, American Journal of Cancer Research, 2015, 5(3): 1158-1168.
4. Nan Li*, Anliu Tang, Shuo Huang, Zeng Li, Xiayu Li, Shourong Shen, Jian Ma, Xiaoyan Wang. MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway, Molecular and Cellular Biochemistry, 2013, 380(1-2): 107-119.
5. Anliu Tang, Nan Li*, Xiayu Li, Hongyuan Yang, Wei Wang, Liyang Zhang, Guiyuan Li, Wei Xiong, Jian Ma, Shourong Shen. Dynamic activation of the key pathway:linking colitis tocolorectal cancer in mouse model, Carcinogenesis, 2012, 33(7): 1375-1383.
6. Li Zhihui, Zhang Jialei, Yin Jiang, Ma wen, Liao Hongfan, Ling Lv, Zou Qingfeng, Song Ying, Zheng Guopei, Hu Xiaoye, Yang Guohua, Li Nan#. Targeting MYOF Suppresses Pancreatic Ductal Adenocarcinoma Progression by Inhibiting ILF3-LCN2 SignalingThrough Disrupting OTUB1-Mediated Deubiquitination of ILF3. Redox Biology（修稿中）
7. Jianlei Zhang, Zhihui Li, Wen Ma, Weina Fan, Jing Dong, Jingjie Tian, Hongfan Liao, Yabing Cao, Qiong Zhang, Jiang Yin, Guopei Zheng, Nan Li#. LAMA4+ cancer-associated fibroblasts provide immunosuppressive microenvironment for liver cancer via induction of T-cell senescence. Cell Communication and Signaling （已于2025-02-25（第二次小修，修回）
